Abnormalities in Brain and Muscle Microstructure and Neurochemistry of the DMD Rat Measured by in vivo Diffusion Tensor Imaging and High Resolution Localized 1 H MRS

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Abnormalities in Brain and Muscle Microstructure and Neurochemistry of the DMD Rat Measured by in vivo Diffusion Tensor Imaging and High Resolution Localized 1 H MRS

Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by the lack of dystrophin by progressive degeneration of the skeletal muscles. Most studies on DMD understandable focus on the muscles, but the dystrophin also expressed in the central nervous system, potentially resulting in cognitive and behavioral changes.

Animal models are used to develop a more comprehensive neuromonitoring protocols and clinical image acquisition procedure. DMD mice have recently developed an animal model that is aligned with progressive muscle wasting seen in DMD. Here, we studied the brains and temporalis muscle structure and neurochemistry of the wild type (WT) and dystrophic (DMD) mice using magnetic resonance imaging and spectroscopy.

Both structural and neurochemical changes observed in the brains of mice DMD and temporalis muscles. There was a decrease in brain volume absolute (WT = 1579 mm3; DMD = 1501 mm3; p = 0.039, Cohen d = 1.867), but not normalized (WT = 4.27; DMD = 4.02; p = 0.306) in brain volume. Diffusion tensor imaging (DTI) revealed structural changes in DMD temporalis muscle, with an increase in mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD).

In DMD mice thalamus, DTI revealed an increase in fractional anisotropy (FA) and a decrease RD. Smaller volume of normal brain correlated with the severity of muscular dystrophy (r = -0.975). neurochemical changes in the brains of mice DMD including increased GABA and NAA in the prefrontal cortex, and GABA in the hippocampus. The findings could indicate impaired motor and sensory signals, generating dysfunctional GABAergic neurotransmission and brain osmoregulasi unstable in dystrophin-zero.

Abnormalities in <em>Brain</em> and Muscle Microstructure and Neurochemistry of the DMD Rat Measured by <i>in vivo</i> Diffusion Tensor Imaging and High Resolution Localized <sup><em>1</em></sup> H MRS
Abnormalities in Brain and Muscle Microstructure and Neurochemistry of the DMD Rat Measured by in vivo Diffusion Tensor Imaging and High Resolution Localized 1 H MRS

heterozygous disruption of Beclin one alleviate arsenite-induced neurobehavioral deficits intestine via reshape microbiota- brain axis

Gut microbiota closely involved in many aspects of human health. expouse arsenite can disrupt the intestinal microbiota and individuals associated with increased susceptibility to diseases related to arsenit-. However, how the microbiome factors influence arsenite-induced neurotoxicity are still largely unknown.

In this study, after treating a healthy adult female mice with arsenite through drinking water for 6 months, our results clearly indicate that chronic exposure to arsenite not only disturbed gut microbiota composition but also cause neurobehavioral dysfunction, manifested with learning and memory deficits and dismay such behavior. Given that an overactive autophagy directly lead to intestinal pathological changes, we further assess whether inhibition of autophagy with average genetics can reverse the arsenite-induced neurobehavioral dysfunction.

Our results are illustrated for the first time that the heterozygous disruption of Beclin 1, which plays a central role in autophagy, alleviate intestinal disorders microbiome phenotype caused by arsenite, and ultimately lead to an increase in neurobehavioral deficits through the gut-brain communication. These findings provide new clues that regulation of autophagy is a potential approach to investigate the functional impact of arsenite on intestinal microbiome, and also can be cut as a way to strategy arsenite protection against neurotoxicity.

MM-102
B1582-20 20 mg
EUR 593
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.
MM-102
B1582-5 5 mg
EUR 212
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.
MM-102
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MM-102
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PPQ-102
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PPQ-102
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PM 102
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MM-102
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LSZ-102
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EUR 3321
p38 Antibody
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p38 Antibody
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p38 Antibody
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EUR 239
p38 antibody
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EUR 268
Description: Purified Polyclonal p38 antibody
p38 antibody
70R-51506 100 ul
EUR 287
Description: Purified Polyclonal p38 antibody
p38 Antibody
20-abx007541
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p38 protein
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EUR 408
p38 protein
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p38 Antibody
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EUR 481
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anti-p38
YF-PA11120 50 ug
EUR 363
Description: Mouse polyclonal to p38
anti-p38
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EUR 403
Description: Rabbit polyclonal to p38
anti-p38
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EUR 334
Description: Mouse polyclonal to p38
anti-p38
YF-PA23520 50 ul
EUR 334
Description: Mouse polyclonal to p38
anti-p38
YF-PA23521 50 ul
EUR 334
Description: Mouse polyclonal to p38
LB (Lennox)
102 500 g
EUR 101
BP-1-102
HY-100493 100mg
EUR 1345
MM-102 (TFA)
HY-12220A 10mM/1mL
EUR 263
SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor
E1B1863 1mg
EUR 161
P38 delta protein
30R-2868 5 ug
EUR 503
Description: Purified recombinant Human P38 delta protein
p38 alpha protein
30R-2870 5 ug
EUR 503
Description: Purified recombinant Human p38 alpha protein
p38 beta protein
30R-2875 5 ug
EUR 503
Description: Purified recombinant Human p38 beta protein
p38 MAPK antibody
20R-1572 100 ug
EUR 705
Description: Rabbit polyclonal p38 MAPK antibody
P38 MAPK antibody
20R-2087 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody
P38 MAPK antibody
20R-2088 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody
P38 MAPK antibody
20R-2403 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody
p38 MAPK antibody
20R-2950 100 ul
EUR 393
Description: Rabbit polyclonal p38 MAPK antibody
p38 MAPK antibody
10R-8422 100 ul
EUR 393
Description: Mouse monoclonal p38 MAPK antibody
p38 MAPK Antibody
49379-100ul 100ul
EUR 333
p38 MAPK Antibody
49379-50ul 50ul
EUR 239
p38 Polyclonal Antibody
41305-100ul 100ul
EUR 252
p38 Polyclonal Antibody
41305-50ul 50ul
EUR 187
p38 Polyclonal Antibody
41306-100ul 100ul
EUR 252
p38 Polyclonal Antibody
41306-50ul 50ul
EUR 187
Anti-p38 alpha
DB-1039 100 tests
EUR 474
Anti-p38 beta
DB-1040 100 tests
EUR 474
Anti-p38 gamma
DB-1041 100 tests
EUR 474
Anti-p38 delta
DB-1042 100 tests
EUR 474
Anti-p38-a
DB-161-0.05 50 μl
EUR 269
Anti-p38-a
DB-161-0.1 100 μl
EUR 422
Anti-p38-b
DB-162-0.05 50 μl
EUR 269
Anti-p38-b
DB-162-0.1 100 μl
EUR 422
Anti-p38-g
DB-163-0.05 50 μl
EUR 269
Anti-p38-g
DB-163-0.1 100 μl
EUR 422
Anti-p38-d
DB-164-0.05 50 μl
EUR 269
Anti-p38-d
DB-164-0.1 100 μl
EUR 422
Anti-p38 alpha
DB1039 100 tests
EUR 474
Anti-p38 beta
DB1040 100 tests
EUR 474
Anti-p38 gamma
DB1041 100 tests
EUR 474
Anti-p38 delta
DB1042 100 tests
EUR 474
p38 beta, Active
7763-100
EUR 4345
p38 beta, Active
7763-5
EUR 370
Anti-p38 Antibody
A00176 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.
p38 MAPK antibody
70R-33398 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody
p38 MAPK antibody
70R-33400 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody
P38 MAPK antibody
70R-34325 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody
P38 MAPK antibody
70R-34327 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody
p38 (pT180) Antibody
20-abx009863
  • EUR 314.00
  • EUR 467.00
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p38 (pY323) Antibody
20-abx133058
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p38 (pY182) Antibody
20-abx134951
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  • EUR 230.00
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p38 Blocking Peptide
20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
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p38 MAPK Antibody
20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
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  • 100 ug
  • 10 ug
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p38 MAPK Antibody
20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.
p38 Blocking Peptide
20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg
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20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
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p38 MAPK Antibody
AF6455 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.
p38 MAPK Antibody
AF6456 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.
p38 MAPK Antibody
AF6457 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.
p38 MAPK Antibody
abx236077-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.
p38 Polyclonal Antibody
ABP53838-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
p38 Polyclonal Antibody
ABP53838-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
p38 Polyclonal Antibody
ABP53838-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
p38 Polyclonal Antibody
ABP53839-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
p38 Polyclonal Antibody
ABP53839-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
p38 Polyclonal Antibody
ABP53839-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
p38 MAPK Antibody
ABF6456 100 ug
EUR 438
p38 Polyclonal Antibody
ABP52112-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
p38 Polyclonal Antibody
ABP52112-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
p38 Polyclonal Antibody
ABP52112-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
p38 Polyclonal Antibody
ABP52113-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
p38 Polyclonal Antibody
ABP52113-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
p38 Polyclonal Antibody
ABP52113-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
p38 Polyclonal Antibody
ABP57354-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
p38 Polyclonal Antibody
ABP57354-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
p38 Polyclonal Antibody
ABP57354-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
anti- p38 antibody
FNab06076 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IF: 1:20-1:200
  • IHC: 1:50-1:500
  • Immunogen: mitogen-activated protein kinase 14
  • Uniprot ID: Q16539
  • Gene ID: 1432
  • Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction
Description: Antibody raised against p38
p38 Polyclonal Antibody
ES8347-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA
p38 Polyclonal Antibody
ES8347-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA
p38 Polyclonal Antibody
ES3111-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
p38 Polyclonal Antibody
ES3111-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
p38 Polyclonal Antibody
ES3112-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
p38 Polyclonal Antibody
ES3112-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
p38 Polyclonal Antibody
ES4837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
p38 Polyclonal Antibody
ES4837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA
p38 Polyclonal Antibody
ES4838-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
p38 Polyclonal Antibody
ES4838-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA
anti-p38 MAPK
LF-PA0160 100 ul
EUR 334
Description: Rabbit polyclonal to p38 MAPK
Anti-p38 antibody
PAab06076 100 ug
EUR 355
p38 alpha-MAPK14
RA15053 100 ug
EUR 526
Anti-p38 antibody
STJ94876 200 µl
EUR 197
Description: Rabbit polyclonal to p38.
Anti-p38 antibody
STJ94877 200 µl
EUR 197
Description: Rabbit polyclonal to p38.
Anti-p38 antibody
STJ94878 200 µl
EUR 197
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.
Anti-p38 antibody
STJ94879 200 µl
EUR 197
Description: Rabbit polyclonal to p38.
Anti-p38 antibody
STJ97615 200 µl
EUR 197
Description: Rabbit polyclonal to p38.
Anti-P38 antibody
STJ98898 200 µl
EUR 197
Description: Mouse monoclonal to P38.
Anti-P38 antibody
STJ98899 200 µl
EUR 197
Description: Mouse monoclonal to P38.
Anti-p38 (3D5)
YF-MA12551 200 ul
EUR 363
Description: Mouse monoclonal to p38
Anti-p38 (1C9)
YF-MA12552 100 ug
EUR 363
Description: Mouse monoclonal to p38
anti-Crk p38
YF-PA11088 50 ul
EUR 363
Description: Mouse polyclonal to Crk p38
anti-Crk p38
YF-PA11089 50 ug
EUR 363
Description: Mouse polyclonal to Crk p38
anti-Crk p38
YF-PA11090 100 ug
EUR 403
Description: Rabbit polyclonal to Crk p38
anti-AIMP2/p38
YF-PA15507 50 ug
EUR 363
Description: Mouse polyclonal to AIMP2/p38
anti-Crk p38
YF-PA23509 50 ul
EUR 334
Description: Mouse polyclonal to Crk p38
Biotin-MBP(94 - 102)
5-00804 4 x 5mg Ask for price
CART (55-102) (rat)
B5412-.1 100 ug
EUR 502
CART (55-102) (human)
B5413-.1 100 ug
EUR 447
HG-10-102-01
B1262-10 10 mg
EUR 303
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].
HG-10-102-01
B1262-25 25 mg
EUR 502
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].
HG-10-102-01
B1262-5 5 mg
EUR 193
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].
HG-10-102-01
B1262-5.1 10 mM (in 1mL DMSO)
EUR 192
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].
HG-10-102-01
B1262-50 50 mg
EUR 821
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].
Polyclonal SAP 102 Antibody
APR13193G 0.05ml
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SAP 102 . This antibody is tested and proven to work in the following applications:
HG-10-102-01
HY-13488 10mM/1mL
EUR 219
CART (55-102) (human)
H-4444.0100 0.1mg
EUR 393
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]
CART (55-102) (human)
H-4444.0500 0.5mg
EUR 1482
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]
CART (55-102) (human)
H-4444.1000 1.0mg
EUR 2207
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]
CART (55-102) (rat)
H-4446.0100 0.1mg
EUR 393
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]
CART (55-102) (rat)
H-4446.0500 0.5mg
EUR 1482
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]
CART (55-102) (rat)
H-4446.1000 1.0mg
EUR 2207
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]
Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit
abx197397-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit
EM1199 96T
EUR 524.1
  • Detection range: 1.25-80 ng/ml
  • Alias: MAPK P38
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml
p38 MAP Kinase antibody
20R-1458 100 ug
EUR 673
Description: Rabbit polyclonal p38 MAP Kinase antibody
p38 MAP Kinase Antibody
3114-100
EUR 343
p38 MAP Kinase Antibody
3114-30T
EUR 146
p38 MAPK Monoclonal Antibody
27507-100ul 100ul
EUR 252
p38 MAPK Monoclonal Antibody
27507-50ul 50ul
EUR 187
p38 MAP Kinase antibody
70R-11620 100 ug
EUR 418
Description: Rabbit polyclonal p38 MAP Kinase antibody
Phospho-p38 MAPK antibody
70R-11824 100 ug
EUR 525
Description: Rabbit polyclonal Phospho-p38 MAPK antibody
p38 MAPK Rabbit pAb
A10832-100ul 100 ul
EUR 384
p38 MAPK Rabbit pAb
A10832-200ul 200 ul
EUR 554
p38 MAPK Rabbit pAb
A10832-20ul 20 ul
EUR 183
p38 MAPK Rabbit pAb
A10832-50ul 50 ul
EUR 265
p38 MAPK Rabbit pAb
A11340-100ul 100 ul
EUR 308
p38 MAPK Rabbit pAb
A11340-200ul 200 ul
EUR 459
p38 MAPK Rabbit pAb
A11340-20ul 20 ul
EUR 183
p38 MAPK Rabbit pAb
A11340-50ul 50 ul
EUR 223
p38 MAPK Rabbit pAb
A14401-100ul 100 ul
EUR 308
p38 MAPK Rabbit pAb
A14401-200ul 200 ul
EUR 459
p38 MAPK Rabbit pAb
A14401-20ul 20 ul
EUR 183
p38 MAPK Rabbit pAb
A14401-50ul 50 ul
EUR 223
Phospho-p38 MAPK Antibody
3438-100
EUR 425


iSNAP preparation consists of pulsed arterial spin labeling and gold corner radial 3D acquisition. Image reconstructed by the method of weighted k-space image contrast (KWIC) with optimized data sharing strategy. Dynamic MRA for the assessment of blood flow obtained from iSNAP by reconstruction in several times inversion and subtraction images, static MRA by the second image reduction approach and phase inversion recovery technique-sensitive, and the vessel wall by the second image reconstruction

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