Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

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Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Brain tumors are the most common pediatric solid neoplasm and the major cause of cancer-related morbidity of childhood and death. While most of the adult brain tumor appears in the brain supratentorial and large, the majority of brain tumors in children are infratentorial and arising in the posterior fossa, especially the cerebellum. Results from a malignant tumor of the cerebellum can not be accepted despite aggressive treatment (surgery, radiation and / or chemotherapy) that are harmful to brain development. Novel treatments / oncolytic virotherapy approach is needed.

Preclinical and clinical studies have previously shown that genetically engineered herpes simplex virus oncolytic (HSV-1) G207 safely can target a malignancy cerebellar and has the potential to induce an immune response anti-tumor on local sites and away from the disease, including metastatic spine disease and leptomeningeal. Here, we outline the rationale, design and significance of the first clinical trial the first-in-humans Phase immunotherapy targeting malignancy cerebellar recurrent HSV G207 in combination with low doses of radiation alone (5 Gy), designed to increase the replication of the virus and the innate and adaptive immune responses.

We discuss the unique challenges of intratumoral inoculation with the virus via the catheter into the tumor of the cerebellum. trial using one arm, open-label, the traditional 3 + 3 design with four dose cohorts. The main objective is to assess the safety and tolerability of a G207 with radiation in recurrent / progressive cerebellar malignant tumor of children. After a biopsy to prove relapse / progress, 1-4 intratumoral catheter will be placed followed by controlled-level G207 infusion over 6 hours followed by the removal of the catheter at the bedside.

Radiation will be given within 24 hours of virus inoculation. Patients will be closely monitored for toxicity and viral shedding. Efficacy will be assessed by measuring the response of radiography, the performance scores, progression-free and overall survival, and quality of life. The data obtained will be invaluable in our efforts to produce therapies more effective and less toxic to children with high-grade brain tumors.

Design and Rationale for First-In-Human Phase <em>1</em> Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar <em>Brain</em> Tumors
Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Cerebrospinal Fluid of amyloid beta, Level Tau, apolipoprotein, and one H-MRS Brain metabolites in Alzheimer’s Disease: A Systematic Review

Background: There is strong evidence that the neurochemical changes measured by proton magnetic resonance spectroscopy (1H-MRS) occur at different phases of Alzheimer’s disease (AD). However, the extent of neurochemical changes associated with AD biomarkers are validated and / or apolipoprotein (APOE) ε4 not yet been established.


Objectives: This systematic review analyzing the evidence provided in (1) changes in neurochemistry; and (2) the relationship between brain metabolites and validated cerebrospinal fluid biomarkers, and / or APOE in AD.


Methods: PubMed, Cochrane, Scopus, and gray literature were systematically screened for the study deemed suitable for the purpose of the current systematic review.


Results: Twenty-four articles met the inclusion criteria. Decreased levels of N-acetyl aspartate (NAA), NAA / (creatine) Cr and NAA / (myo-inositol) ml, and increased ml, ml / Cr, Cho (choline) / Cr, ml / NAA was found in the posterior cingulate cortex / precuneus. Ml increase was associated with increased levels of tau, reduced NAA / Cr is associated with increased tau. ml / Cr was negatively correlated with Aβ42, and ml / Cr was positively correlated with t-tau.

MM-102
B1582-5 5 mg
EUR 212
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102
B2364-25
EUR 588

MM-102
B2364-5
EUR 185

PPQ-102
B3504-10 10 mg
EUR 242

PPQ-102
B3504-5 5 mg
EUR 151

PPQ-102
B3504-50 50 mg
EUR 863

PM 102
B5517-1 1 mg
EUR 601

MM-102
HY-12220 10mg
EUR 298

IAXO-102
HY-125171 50mg
EUR 1944

PPQ-102
HY-14179 100mg
EUR 1221

BGB-102
HY-15732 10mg
EUR 6041

EL-102
HY-16187 10mM/1mL
EUR 376

LSZ-102
HY-111486 50mg
EUR 3321

p38 Antibody
35478-100ul 100ul
EUR 390

p38 Antibody
48644-100ul 100ul
EUR 333

p38 Antibody
48644-50ul 50ul
EUR 239

p38 antibody
70R-51505 100 ul
EUR 268
Description: Purified Polyclonal p38 antibody

p38 antibody
70R-51506 100 ul
EUR 287
Description: Purified Polyclonal p38 antibody

p38 Antibody
20-abx007541
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody
20-abx133223
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Antibody
20-abx141038
  • EUR 356.00
  • EUR 537.00
  • EUR 217.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 protein
E20-80078 20ug
EUR 408

p38 protein
E20-80079 20ug
EUR 408

p38 Antibody
abx236076-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

anti-p38
YF-PA11120 50 ug
EUR 363
Description: Mouse polyclonal to p38

anti-p38
YF-PA11121 100 ug
EUR 403
Description: Rabbit polyclonal to p38

anti-p38
YF-PA23519 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38
YF-PA23520 50 ul
EUR 334
Description: Mouse polyclonal to p38

anti-p38
YF-PA23521 50 ul
EUR 334
Description: Mouse polyclonal to p38

LB (Lennox)
102 500 g
EUR 101

BP-1-102
HY-100493 100mg
EUR 1345

MM-102 (TFA)
HY-12220A 10mM/1mL
EUR 263

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor
E1B1863 1mg
EUR 161

P38 delta protein
30R-2868 5 ug
EUR 503
Description: Purified recombinant Human P38 delta protein

p38 alpha protein
30R-2870 5 ug
EUR 503
Description: Purified recombinant Human p38 alpha protein

p38 beta protein
30R-2875 5 ug
EUR 503
Description: Purified recombinant Human p38 beta protein

p38 MAPK antibody
20R-1572 100 ug
EUR 705
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody
20R-2087 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
20R-2088 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
20R-2403 50 ug
EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody
20R-2950 100 ul
EUR 393
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody
10R-8422 100 ul
EUR 393
Description: Mouse monoclonal p38 MAPK antibody

p38 MAPK Antibody
49379-100ul 100ul
EUR 333

p38 MAPK Antibody
49379-50ul 50ul
EUR 239

p38 Polyclonal Antibody
41305-100ul 100ul
EUR 252

p38 Polyclonal Antibody
41305-50ul 50ul
EUR 187

p38 Polyclonal Antibody
41306-100ul 100ul
EUR 252

p38 Polyclonal Antibody
41306-50ul 50ul
EUR 187

Anti-p38 alpha
DB-1039 100 tests
EUR 474

Anti-p38 beta
DB-1040 100 tests
EUR 474

Anti-p38 gamma
DB-1041 100 tests
EUR 474

Anti-p38 delta
DB-1042 100 tests
EUR 474

Anti-p38-a
DB-161-0.05 50 μl
EUR 269

Anti-p38-a
DB-161-0.1 100 μl
EUR 422

Anti-p38-b
DB-162-0.05 50 μl
EUR 269

Anti-p38-b
DB-162-0.1 100 μl
EUR 422

Anti-p38-g
DB-163-0.05 50 μl
EUR 269

Anti-p38-g
DB-163-0.1 100 μl
EUR 422

Anti-p38-d
DB-164-0.05 50 μl
EUR 269

Anti-p38-d
DB-164-0.1 100 μl
EUR 422

Anti-p38 alpha
DB1039 100 tests
EUR 474

Anti-p38 beta
DB1040 100 tests
EUR 474

Anti-p38 gamma
DB1041 100 tests
EUR 474

Anti-p38 delta
DB1042 100 tests
EUR 474

p38 beta, Active
7763-100
EUR 4345

p38 beta, Active
7763-5
EUR 370

Anti-p38 Antibody
A00176 100ul
EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 MAPK antibody
70R-33398 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody
70R-33400 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody
70R-34325 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
70R-34327 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

p38 (pT180) Antibody
20-abx009863
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 (pY323) Antibody
20-abx133058
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 (pY182) Antibody
20-abx134951
  • EUR 384.00
  • EUR 606.00
  • EUR 230.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 Blocking Peptide
20-abx161932
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK Antibody
20-abx012798
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

p38 MAPK Antibody
20-abx012875
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

p38 Blocking Peptide
20-abx061736
  • EUR 258.00
  • EUR 384.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 Blocking Peptide
20-abx062080
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK Antibody
AF6455 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody
AF6456 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody
AF6457 200ul
EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody
abx236077-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

p38 Polyclonal Antibody
ABP53838-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53838-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53838-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53839-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody
ABP53839-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody
ABP53839-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 MAPK Antibody
ABF6456 100 ug
EUR 438

p38 Polyclonal Antibody
ABP52112-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52112-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52112-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52113-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody
ABP52113-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody
ABP52113-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody
ABP57354-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody
ABP57354-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody
ABP57354-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the C-terminal region of human p38
  • Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

anti- p38 antibody
FNab06076 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IF: 1:20-1:200
  • IHC: 1:50-1:500
  • Immunogen: mitogen-activated protein kinase 14
  • Uniprot ID: Q16539
  • Gene ID: 1432
  • Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction
Description: Antibody raised against p38

p38 Polyclonal Antibody
ES8347-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody
ES8347-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody
ES3111-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES3111-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES3112-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES3112-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4837-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4837-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4838-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES4838-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

anti-p38 MAPK
LF-PA0160 100 ul
EUR 334
Description: Rabbit polyclonal to p38 MAPK

Anti-p38 antibody
PAab06076 100 ug
EUR 355

p38 alpha-MAPK14
RA15053 100 ug
EUR 526

Anti-p38 antibody
STJ94876 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ94877 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ94878 200 µl
EUR 197
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody
STJ94879 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ97615 200 µl
EUR 197
Description: Rabbit polyclonal to p38.

Anti-P38 antibody
STJ98898 200 µl
EUR 197
Description: Mouse monoclonal to P38.

Anti-P38 antibody
STJ98899 200 µl
EUR 197
Description: Mouse monoclonal to P38.

Anti-p38 (3D5)
YF-MA12551 200 ul
EUR 363
Description: Mouse monoclonal to p38

Anti-p38 (1C9)
YF-MA12552 100 ug
EUR 363
Description: Mouse monoclonal to p38

anti-Crk p38
YF-PA11088 50 ul
EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11089 50 ug
EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11090 100 ug
EUR 403
Description: Rabbit polyclonal to Crk p38

anti-AIMP2/p38
YF-PA15507 50 ug
EUR 363
Description: Mouse polyclonal to AIMP2/p38

anti-Crk p38
YF-PA23509 50 ul
EUR 334
Description: Mouse polyclonal to Crk p38

Biotin-MBP(94 - 102)
5-00804 4 x 5mg Ask for price

CART (55-102) (rat)
B5412-.1 100 ug
EUR 502

CART (55-102) (human)
B5413-.1 100 ug
EUR 447

HG-10-102-01
B1262-10 10 mg
EUR 303
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-25 25 mg
EUR 502
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-5 5 mg
EUR 193
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-5.1 10 mM (in 1mL DMSO)
EUR 192
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-50 50 mg
EUR 821
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

Polyclonal SAP 102 Antibody
APR13193G 0.05ml
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SAP 102 . This antibody is tested and proven to work in the following applications:

HG-10-102-01
HY-13488 10mM/1mL
EUR 219

CART (55-102) (human)
H-4444.0100 0.1mg
EUR 393
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)
H-4444.0500 0.5mg
EUR 1482
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)
H-4444.1000 1.0mg
EUR 2207
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (rat)
H-4446.0100 0.1mg
EUR 393
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)
H-4446.0500 0.5mg
EUR 1482
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)
H-4446.1000 1.0mg
EUR 2207
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit
abx197397-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit
EM1199 96T
EUR 524.1
  • Detection range: 1.25-80 ng/ml
  • Alias: MAPK P38
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml

p38 MAP Kinase antibody
20R-1458 100 ug
EUR 673
Description: Rabbit polyclonal p38 MAP Kinase antibody

p38 MAP Kinase Antibody
3114-100
EUR 343

p38 MAP Kinase Antibody
3114-30T
EUR 146

p38 MAPK Monoclonal Antibody
27507-100ul 100ul
EUR 252

p38 MAPK Monoclonal Antibody
27507-50ul 50ul
EUR 187

p38 MAP Kinase antibody
70R-11620 100 ug
EUR 418
Description: Rabbit polyclonal p38 MAP Kinase antibody

Phospho-p38 MAPK antibody
70R-11824 100 ug
EUR 525
Description: Rabbit polyclonal Phospho-p38 MAPK antibody

p38 MAPK Rabbit pAb
A10832-100ul 100 ul
EUR 384

p38 MAPK Rabbit pAb
A10832-200ul 200 ul
EUR 554

p38 MAPK Rabbit pAb
A10832-20ul 20 ul
EUR 183

p38 MAPK Rabbit pAb
A10832-50ul 50 ul
EUR 265

p38 MAPK Rabbit pAb
A11340-100ul 100 ul
EUR 308

p38 MAPK Rabbit pAb
A11340-200ul 200 ul
EUR 459

p38 MAPK Rabbit pAb
A11340-20ul 20 ul
EUR 183

p38 MAPK Rabbit pAb
A11340-50ul 50 ul
EUR 223

p38 MAPK Rabbit pAb
A14401-100ul 100 ul
EUR 308

p38 MAPK Rabbit pAb
A14401-200ul 200 ul
EUR 459

p38 MAPK Rabbit pAb
A14401-20ul 20 ul
EUR 183

p38 MAPK Rabbit pAb
A14401-50ul 50 ul
EUR 223

Phospho-p38 MAPK Antibody
3438-100
EUR 425

Polyclonal MAPK14 / p38 Antibody
APR02822G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MAPK14 / p38 . This antibody is tested and proven to work in the following applications:

p38 gamma/delta Antibody
DF10341 200ul
EUR 304
Description: p38-delta/gamma Antibody detects endogenous levels of p38-delta/gamma.

p38 MAPK antibody (Thr180)
70R-37313 100 ug
EUR 349
Description: Rabbit Polyclonal p38 MAPK antibody (Thr180)

p38 MAPK antibody (Tyr182)
70R-37314 100 ug
EUR 349
Description: Rabbit Polyclonal p38 MAPK antibody (Tyr182)

p38 MAPK antibody (Tyr322)
70R-33397 100 ug
EUR 327
Description: Rabbit polyclonal p38 MAPK antibody (Tyr322)

P38 MAPK antibody (Thr179)
70R-34324 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody (Thr179)

P38 MAPK antibody (Tyr182)
70R-34326 100 ug
EUR 327
Description: Rabbit polyclonal P38 MAPK antibody (Tyr182)

p38 (pT180 / Y182) Antibody
20-abx133560
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

p38 (pY323) Blocking Peptide
20-abx161669
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK (pT180) Antibody
abx011783-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

p38 MAPK (pY182) Antibody
20-abx011784
  • EUR 439.00
  • EUR 91.00
  • EUR 77.00
  • 100 ug
  • 10 ug
  • 5 ug
  • Shipped within 5-10 working days.

p38 MAPK (pY322) Antibody
20-abx011785
  • EUR 439.00
  • EUR 91.00
  • 100 ug
  • 10 ug
  • Shipped within 5-10 working days.

p38 (pY182) Blocking Peptide
20-abx061650
  • EUR 300.00
  • EUR 495.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 (pT180) Blocking Peptide
20-abx062081
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

p38 MAPK Conjugated Antibody
C49379 100ul
EUR 397

p38 MAPK Blocking Peptide
AF6455-BP 1mg
EUR 195

p38 MAPK Blocking Peptide
AF6456-BP 1mg
EUR 195

p38 MAPK Blocking Peptide
AF6457-BP 1mg
EUR 195

p38 Polyclonal Conjugated Antibody
C41305 100ul
EUR 397

p38 MAPK Rabbit pAb
A8038-100ul 100 ul
EUR 308

p38 MAPK Rabbit pAb
A8038-200ul 200 ul
EUR 459

p38 MAPK Rabbit pAb
A8038-20ul 20 ul Ask for price

p38 MAPK Rabbit pAb
A8038-50ul 50 ul Ask for price

p38 MAPK Rabbit pAb
A5521-100ul 100 ul
EUR 308

p38 MAPK Rabbit pAb
A5521-200ul 200 ul
EUR 459

p38 MAPK Rabbit pAb
A5521-20ul 20 ul
EUR 183

p38 MAPK Rabbit pAb
A5521-50ul 50 ul
EUR 223

p38 MAPK Polyclonal Antibody
ABP59793-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from part region of human p38 MAPK protein
  • Applications tips:
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein

p38 MAPK Polyclonal Antibody
ABP59793-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from part region of human p38 MAPK protein
  • Applications tips:
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein

NAA and reduced glutathione levels in APOE ε4 carriers. APOE ε4 modulatory exerts no effect on the NAA / Cr. There is an interaction between APOE ε4, Aβ42, and ml / Cr.
Conclusion: NAA, ml, NAA / Cr, NAA / ml and ml / Cr may be potentially useful biomarkers that might highlight the functional changes in the clinical stage of AD.

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