Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Brain tumors are the most common pediatric solid neoplasm and the major cause of cancer-related morbidity of childhood and death. While most of the adult brain tumor appears in the brain supratentorial and large, the majority of brain tumors in children are infratentorial and arising in the posterior fossa, especially the cerebellum. Results from a malignant tumor of the cerebellum can not be accepted despite aggressive treatment (surgery, radiation and / or chemotherapy) that are harmful to brain development. Novel treatments / oncolytic virotherapy approach is needed.

Preclinical and clinical studies have previously shown that genetically engineered herpes simplex virus oncolytic (HSV-1) G207 safely can target a malignancy cerebellar and has the potential to induce an immune response anti-tumor on local sites and away from the disease, including metastatic spine disease and leptomeningeal. Here, we outline the rationale, design and significance of the first clinical trial the first-in-humans Phase immunotherapy targeting malignancy cerebellar recurrent HSV G207 in combination with low doses of radiation alone (5 Gy), designed to increase the replication of the virus and the innate and adaptive immune responses.

We discuss the unique challenges of intratumoral inoculation with the virus via the catheter into the tumor of the cerebellum. trial using one arm, open-label, the traditional 3 + 3 design with four dose cohorts. The main objective is to assess the safety and tolerability of a G207 with radiation in recurrent / progressive cerebellar malignant tumor of children. After a biopsy to prove relapse / progress, 1-4 intratumoral catheter will be placed followed by controlled-level G207 infusion over 6 hours followed by the removal of the catheter at the bedside.

Radiation will be given within 24 hours of virus inoculation. Patients will be closely monitored for toxicity and viral shedding. Efficacy will be assessed by measuring the response of radiography, the performance scores, progression-free and overall survival, and quality of life. The data obtained will be invaluable in our efforts to produce therapies more effective and less toxic to children with high-grade brain tumors.

Cerebrospinal Fluid of amyloid beta, Level Tau, apolipoprotein, and ^{one H-MRS Brain metabolites in Alzheimer’s Disease: A Systematic Review}

Background: There is strong evidence that the neurochemical changes measured by proton magnetic resonance spectroscopy (1H-MRS) occur at different phases of Alzheimer’s disease (AD). However, the extent of neurochemical changes associated with AD biomarkers are validated and / or apolipoprotein (APOE) ε4 not yet been established.

Objectives: This systematic review analyzing the evidence provided in (1) changes in neurochemistry; and (2) the relationship between brain metabolites and validated cerebrospinal fluid biomarkers, and / or APOE in AD.

Methods: PubMed, Cochrane, Scopus, and gray literature were systematically screened for the study deemed suitable for the purpose of the current systematic review.

Results: Twenty-four articles met the inclusion criteria. Decreased levels of N-acetyl aspartate (NAA), NAA / (creatine) Cr and NAA / (myo-inositol) ml, and increased ml, ml / Cr, Cho (choline) / Cr, ml / NAA was found in the posterior cingulate cortex / precuneus. Ml increase was associated with increased levels of tau, reduced NAA / Cr is associated with increased tau. ml / Cr was negatively correlated with Aβ42, and ml / Cr was positively correlated with t-tau.

PPQ-102
B3504-10	ApexBio	10 mg	EUR 242

PPQ-102
B3504-5	ApexBio	5 mg	EUR 151

PPQ-102
B3504-50	ApexBio	50 mg	EUR 863

MM-102
B1582-2	ApexBio	2 mg	EUR 128
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102
B1582-20	ApexBio	20 mg	EUR 593
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102
B1582-5	ApexBio	5 mg	EUR 212
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

PM 102
B5517-1	ApexBio	1 mg	EUR 601

LSZ-102
HY-111486	MedChemExpress	50mg	EUR 3321

BGB-102
HY-15732	MedChemExpress	10mg	EUR 6041

EL-102
HY-16187	MedChemExpress	10mM/1mL	EUR 376

MM-102
HY-12220	MedChemExpress	10mg	EUR 298

IAXO-102
HY-125171	MedChemExpress	50mg	EUR 1944

PPQ-102
HY-14179	MedChemExpress	100mg	EUR 1221

p38 protein
E20-80078	EnoGene	20ug	EUR 408

p38 protein
E20-80079	EnoGene	20ug	EUR 408

p38 Antibody
20-abx141038	Abbexa	EUR 356.00 EUR 537.00 EUR 217.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 Antibody
20-abx133223	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 Antibody
20-abx007541	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 Antibody
abx236076-100ug	Abbexa	100 ug	EUR 481
Shipped within 5-12 working days.

p38 antibody
70R-51505	Fitzgerald	100 ul	EUR 268
Description: Purified Polyclonal p38 antibody

p38 antibody
70R-51506	Fitzgerald	100 ul	EUR 287
Description: Purified Polyclonal p38 antibody

p38 Antibody
35478-100ul	SAB	100ul	EUR 390

p38 Antibody
48644-100ul	SAB	100ul	EUR 333

p38 Antibody
48644-50ul	SAB	50ul	EUR 239

anti-p38
YF-PA11120	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to p38

anti-p38
YF-PA11121	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to p38

anti-p38
YF-PA23519	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to p38

anti-p38
YF-PA23520	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to p38

anti-p38
YF-PA23521	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to p38

LB (Lennox)
102	AthenaES	500 g	EUR 101

BP-1-102
HY-100493	MedChemExpress	100mg	EUR 1345

MM-102 (TFA)
HY-12220A	MedChemExpress	10mM/1mL	EUR 263

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor
E1B1863	EnoGene	1mg	EUR 161

p38 MAPK Antibody
AF6455	Affbiotech	200ul	EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody
AF6456	Affbiotech	200ul	EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 MAPK Antibody
AF6457	Affbiotech	200ul	EUR 304
Description: p38 MAPK Antibody detects endogenous levels of total p38 MAPK.

p38 Polyclonal Antibody
ES3111-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES3111-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES3112-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES3112-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4837-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4837-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody
ES4838-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES4838-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody
ES8347-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody
ES8347-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

anti- p38 antibody
FNab06076	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:200-1:2000 IF: 1:20-1:200 IHC: 1:50-1:500 Immunogen: mitogen-activated protein kinase 14 Uniprot ID: Q16539 Gene ID: 1432 Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction
Description: Antibody raised against p38

p38 Polyclonal Antibody
ABP57354-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from the C-terminal region of human p38 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody
ABP57354-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from the C-terminal region of human p38 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody
ABP57354-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from the C-terminal region of human p38 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Blocking Peptide
20-abx161932	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 (pY323) Antibody
20-abx133058	Abbexa	EUR 314.00 EUR 467.00 EUR 203.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 (pY182) Antibody
20-abx134951	Abbexa	EUR 384.00 EUR 606.00 EUR 230.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 Blocking Peptide
20-abx061736	Abbexa	EUR 258.00 EUR 384.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 Blocking Peptide
20-abx062080	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 (pT180) Antibody
20-abx009863	Abbexa	EUR 314.00 EUR 467.00 EUR 203.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 MAPK Antibody
20-abx012798	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

p38 MAPK Antibody
20-abx012875	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

p38 Polyclonal Antibody
ABP53838-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53838-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53838-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody
ABP53839-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody
ABP53839-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody
ABP53839-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 MAPK Antibody
ABF6456	Lifescience Market	100 ug	EUR 438

p38 Polyclonal Antibody
ABP52112-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52112-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52112-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody
ABP52113-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody
ABP52113-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody
ABP52113-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from human p38 around the non-phosphorylation site of Y323 Applications tips:
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 MAPK Antibody
abx236077-100ug	Abbexa	100 ug	EUR 481
Shipped within 5-12 working days.

Anti-p38 Antibody
A00176	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

p38 MAPK antibody
70R-33398	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody
70R-33400	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody
70R-34325	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
70R-34327	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal P38 MAPK antibody

p38 beta, Active
7763-100	Biovision		EUR 4345

p38 beta, Active
7763-5	Biovision		EUR 370

p38 MAPK Antibody
49379-100ul	SAB	100ul	EUR 333

p38 MAPK Antibody
49379-50ul	SAB	50ul	EUR 239

p38 Polyclonal Antibody
41305-100ul	SAB	100ul	EUR 252

p38 Polyclonal Antibody
41305-50ul	SAB	50ul	EUR 187

p38 Polyclonal Antibody
41306-100ul	SAB	100ul	EUR 252

p38 Polyclonal Antibody
41306-50ul	SAB	50ul	EUR 187

p38 MAPK antibody
10R-8422	Fitzgerald	100 ul	EUR 393
Description: Mouse monoclonal p38 MAPK antibody

P38 delta protein
30R-2868	Fitzgerald	5 ug	EUR 503
Description: Purified recombinant Human P38 delta protein

p38 alpha protein
30R-2870	Fitzgerald	5 ug	EUR 503
Description: Purified recombinant Human p38 alpha protein

p38 beta protein
30R-2875	Fitzgerald	5 ug	EUR 503
Description: Purified recombinant Human p38 beta protein

p38 MAPK antibody
20R-1572	Fitzgerald	100 ug	EUR 705
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody
20R-2087	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
20R-2088	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody
20R-2403	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody
20R-2950	Fitzgerald	100 ul	EUR 393
Description: Rabbit polyclonal p38 MAPK antibody

Anti-p38 alpha
DB-1039	DB Biotech	100 tests	EUR 474

Anti-p38 beta
DB-1040	DB Biotech	100 tests	EUR 474

Anti-p38 gamma
DB-1041	DB Biotech	100 tests	EUR 474

Anti-p38 delta
DB-1042	DB Biotech	100 tests	EUR 474

Anti-p38-a
DB-161-0.05	DB Biotech	50 μl	EUR 269

Anti-p38-a
DB-161-0.1	DB Biotech	100 μl	EUR 422

Anti-p38-b
DB-162-0.05	DB Biotech	50 μl	EUR 269

Anti-p38-b
DB-162-0.1	DB Biotech	100 μl	EUR 422

Anti-p38-g
DB-163-0.05	DB Biotech	50 μl	EUR 269

Anti-p38-g
DB-163-0.1	DB Biotech	100 μl	EUR 422

Anti-p38-d
DB-164-0.05	DB Biotech	50 μl	EUR 269

Anti-p38-d
DB-164-0.1	DB Biotech	100 μl	EUR 422

Anti-p38 alpha
DB1039	DB Biotech	100 tests	EUR 474

Anti-p38 beta
DB1040	DB Biotech	100 tests	EUR 474

Anti-p38 gamma
DB1041	DB Biotech	100 tests	EUR 474

Anti-p38 delta
DB1042	DB Biotech	100 tests	EUR 474

Anti-p38 antibody
PAab06076	Lifescience Market	100 ug	EUR 355

anti-p38 MAPK
LF-PA0160	Abfrontier	100 ul	EUR 334
Description: Rabbit polyclonal to p38 MAPK

p38 alpha-MAPK14
RA15053	Neuromics	100 ug	EUR 526

Anti-p38 antibody
STJ94876	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ94877	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ94878	St John's Laboratory	200 µl	EUR 197
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody
STJ94879	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to p38.

Anti-p38 antibody
STJ97615	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to p38.

Anti-P38 antibody
STJ98898	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to P38.

Anti-P38 antibody
STJ98899	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to P38.

Anti-p38 (3D5)
YF-MA12551	Abfrontier	200 ul	EUR 363
Description: Mouse monoclonal to p38

Anti-p38 (1C9)
YF-MA12552	Abfrontier	100 ug	EUR 363
Description: Mouse monoclonal to p38

anti-Crk p38
YF-PA11088	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11089	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to Crk p38

anti-Crk p38
YF-PA11090	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to Crk p38

anti-AIMP2/p38
YF-PA15507	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to AIMP2/p38

anti-Crk p38
YF-PA23509	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to Crk p38

HG-10-102-01
B1262-10	ApexBio	10 mg	EUR 303
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-25	ApexBio	25 mg	EUR 502
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-5	ApexBio	5 mg	EUR 193
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 192
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

HG-10-102-01
B1262-50	ApexBio	50 mg	EUR 821
Description: HG-10-102-01 is a potent and selective inhibitor of leucine-rich repeat kinase 2 (LRRK2) with the IC50 values of 20.3nM and 3.2nM for wild type LRRK2 and LRRK2 [G1019S], respectively [1].

CART (55-102) (rat)
B5412-.1	ApexBio	100 ug	EUR 502

CART (55-102) (human)
B5413-.1	ApexBio	100 ug	EUR 447

Polyclonal SAP 102 Antibody
APR13193G	Leading Biology	0.05ml	EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SAP 102 . This antibody is tested and proven to work in the following applications:

HG-10-102-01
HY-13488	MedChemExpress	10mM/1mL	EUR 219

CART (55-102) (human)
H-4444.0100	Bachem	0.1mg	EUR 393
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)
H-4444.0500	Bachem	0.5mg	EUR 1482
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (human)
H-4444.1000	Bachem	1.0mg	EUR 2207
Description: Sum Formula: C225H365N65O65S7; CAS# [214050-22-3]

CART (55-102) (rat)
H-4446.0100	Bachem	0.1mg	EUR 393
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)
H-4446.0500	Bachem	0.5mg	EUR 1482
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

CART (55-102) (rat)
H-4446.1000	Bachem	1.0mg	EUR 2207
Description: Sum Formula: C226H367N65O65S7; CAS# [209615-79-2]

Biotin-MBP(94 - 102)
5-00804	CHI Scientific	4 x 5mg	Ask for price

Mouse MAPK P38(P38 Mitogen-activated Protein Kinase) ELISA Kit
EM1199	FN Test	96T	EUR 524.1
Detection range: 1.25-80 ng/ml Alias: MAPK P38
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.75 ng/ml

Mouse P38 Mitogen-activated Protein Kinase (MAPK P38) CLIA Kit
abx197397-96tests	Abbexa	96 tests	EUR 825
Shipped within 5-12 working days.

Polyclonal MAPK14 / p38 Antibody
APR02822G	Leading Biology	0.05ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human MAPK14 / p38 . This antibody is tested and proven to work in the following applications:

p38 MAPK Blocking Peptide
AF6455-BP	Affbiotech	1mg	EUR 195

p38 MAPK Blocking Peptide
AF6456-BP	Affbiotech	1mg	EUR 195

p38 MAPK Blocking Peptide
AF6457-BP	Affbiotech	1mg	EUR 195

p38 Polyclonal Conjugated Antibody
C41305	SAB	100ul	EUR 397

p38 MAPK Conjugated Antibody
C49379	SAB	100ul	EUR 397

p38 MAPK-IN-1
HY-12839	MedChemExpress	5mg	EUR 533

p38 MAPK Polyclonal Antibody
ES8901-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against p38 MAPK from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 MAPK Polyclonal Antibody
ES8901-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against p38 MAPK from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

anti- p38 MAPK antibody
FNab06077	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:1000-1:4000 IHC: 1:100-1:400 Immunogen: mitogen-activated protein kinase 14 Uniprot ID: Q16539 Gene ID: 1432 Research Area: Immunology, Cardiovascular, Metabolism, Signal Transduction
Description: Antibody raised against p38 MAPK

p38 MAPK-IN-2
HY-U00324	MedChemExpress	10mg	EUR 3700

P38 (1G1) Monoclonal Antibody
EM1369-100ul	ELK Biotech	100ul	EUR 279
Description: A Mouse Monoclonal antibody against P38 (1G1) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

P38 (1G1) Monoclonal Antibody
EM1369-50ul	ELK Biotech	50ul	EUR 207
Description: A Mouse Monoclonal antibody against P38 (1G1) from Human/ Mouse/ Rat. This antibody is tested and validated for IHC

p38 MAPK Polyclonal Antibody
ABP59793-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from part region of human p38 MAPK protein Applications tips:
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein

p38 MAPK Polyclonal Antibody
ABP59793-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from part region of human p38 MAPK protein Applications tips:
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein

p38 MAPK Polyclonal Antibody
ABP59793-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from part region of human p38 MAPK protein Applications tips:
Description: A polyclonal antibody for detection of p38 MAPK from Human, Mouse, Rat. This p38 MAPK antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human p38 MAPK protein

p38 (pY323) Blocking Peptide
20-abx161669	Abbexa	EUR 314.00 EUR 509.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 (pT180 / Y182) Antibody
20-abx133560	Abbexa	EUR 314.00 EUR 467.00 EUR 203.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

p38 (pY182) Blocking Peptide
20-abx061650	Abbexa	EUR 300.00 EUR 495.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 (pT180) Blocking Peptide
20-abx062081	Abbexa	EUR 314.00 EUR 509.00	1 mg 5 mg
Shipped within 5-10 working days.

p38 MAPK (pT180) Antibody
abx011783-100ug	Abbexa	100 ug	EUR 439
Shipped within 5-10 working days.

p38 MAPK (pY182) Antibody
20-abx011784	Abbexa	EUR 439.00 EUR 91.00 EUR 77.00	100 ug 10 ug 5 ug
Shipped within 5-10 working days.

p38 MAPK (pY322) Antibody
20-abx011785	Abbexa	EUR 439.00 EUR 91.00	100 ug 10 ug
Shipped within 5-10 working days.

p38 MAPK Rabbit pAb
A10832-100ul	Abclonal	100 ul	EUR 384

p38 MAPK Rabbit pAb
A10832-200ul	Abclonal	200 ul	EUR 554

p38 MAPK Rabbit pAb
A10832-20ul	Abclonal	20 ul	EUR 183

p38 MAPK Rabbit pAb
A10832-50ul	Abclonal	50 ul	EUR 265

p38 MAPK Rabbit pAb
A11340-100ul	Abclonal	100 ul	EUR 308

p38 MAPK Rabbit pAb
A11340-200ul	Abclonal	200 ul	EUR 459

p38 MAPK Rabbit pAb
A11340-20ul	Abclonal	20 ul	EUR 183

p38 MAPK Rabbit pAb
A11340-50ul	Abclonal	50 ul	EUR 223

p38 MAPK Rabbit pAb
A5521-100ul	Abclonal	100 ul	EUR 308

p38 MAPK Rabbit pAb
A5521-200ul	Abclonal	200 ul	EUR 459

p38 MAPK Rabbit pAb
A5521-20ul	Abclonal	20 ul	EUR 183

p38 MAPK Rabbit pAb
A5521-50ul	Abclonal	50 ul	EUR 223

p38 MAPK antibody (Thr180)
70R-37313	Fitzgerald	100 ug	EUR 349
Description: Rabbit Polyclonal p38 MAPK antibody (Thr180)

p38 MAPK antibody (Tyr182)
70R-37314	Fitzgerald	100 ug	EUR 349
Description: Rabbit Polyclonal p38 MAPK antibody (Tyr182)

p38 MAPK antibody (Tyr322)
70R-33397	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal p38 MAPK antibody (Tyr322)

P38 MAPK antibody (Thr179)
70R-34324	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal P38 MAPK antibody (Thr179)

P38 MAPK antibody (Tyr182)
70R-34326	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal P38 MAPK antibody (Tyr182)

p38 MAPK Rabbit pAb
A14401-100ul	Abclonal	100 ul	EUR 308

p38 MAPK Rabbit pAb
A14401-200ul	Abclonal	200 ul	EUR 459

p38 MAPK Rabbit pAb
A14401-20ul	Abclonal	20 ul	EUR 183

p38 MAPK Rabbit pAb
A14401-50ul	Abclonal	50 ul	EUR 223

p38 MAPK Rabbit pAb
A8038-100ul	Abclonal	100 ul	EUR 308

p38 MAPK Rabbit pAb
A8038-200ul	Abclonal	200 ul	EUR 459

p38 MAPK Rabbit pAb
A8038-20ul	Abclonal	20 ul	Ask for price

p38 MAPK Rabbit pAb
A8038-50ul	Abclonal	50 ul	Ask for price

Phospho-p38 MAPK Antibody
3438-100	Biovision		EUR 425

NAA and reduced glutathione levels in APOE ε4 carriers. APOE ε4 modulatory exerts no effect on the NAA / Cr. There is an interaction between APOE ε4, Aβ42, and ml / Cr.
Conclusion: NAA, ml, NAA / Cr, NAA / ml and ml / Cr may be potentially useful biomarkers that might highlight the functional changes in the clinical stage of AD.